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ISSN:2454-4116

International Journal of New Technology and Research

Impact Factor 3.953

(An ISO 9001:2008 Certified Online Journal)
India | Germany | France | Japan

Sensitive and Label-free Detection of Cartilage Oligomeric Matrix Protein on Quartz Crystal Microbalance

( Volume 2 Issue 3,March 2016 ) OPEN ACCESS
Author(s):

Chi-Yen Shen, Chun-Lin Wu, Yu-Min Lin, Rey-Chue Hwang

Abstract:

Osteoarthritis (OA), the most common joint disease, is due to articular cartilage degradation, leading to joint destruction. The most common methods for diagnosing OA are done using radiographs and enzyme-linked immunosorbent assay (ELISA) method which are specific but require specialized laboratory facilities and highly trained personal. To avoid invasive methods for diagnosis, the current study describes a novel non-invasive detection method for osteoarthritis urine biomarkers. A highly selective and specific monoclonal antibodies, cartilage oligomeric matrix protein (COMP), were used to immobilize on a quartz crystal microbalance (QCM) sensor. The developed QCM sensor for COMP detection showed good sensitivity, linearity, specificity and reliability.

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