Click Here for
Track Your Paper
ISSN:2454-4116

International Journal of New Technology and Research

Impact Factor 3.953

(An ISO 9001:2008 Certified Online Journal)
India | Germany | France | Japan

Novel Peptide Suppresses Gene Expressions of C-MYC and CCND1 in Kasumi-1 Cell Lines

( Volume 1 Issue 3,July 2015 ) OPEN ACCESS
Author(s):

ChiyoMizuochi-Yanagi, Akane Yonehara, Yuka Tanaka, AnthonySwain, Toshiyuki Tsunoda, Senji Shirasawaand, Daisuke Sugiyama

Abstract:

Leukemias are disorders that cause the abnormal growth and differentiation of hematopoietic cells. Therapies for leukemia are often invasive and there is no guarantee of a positive outcome. Biologically active peptides are being used for a number of therapies for different diseases. We derived several biologically active peptides from fetal liver derived Delta like-1+ hepatoblasts with the intention of finding novel biologically active peptides for the treatment of leukemia. After screening 9 peptides we discovered that two of the peptides caused changes of cell number in the human leukemic cell line Kasumi-1. Further investigation showed that a peptide with the sequence RRRRRRRR(PEG3)CQKKDGPCVINGS also caused suppression of the C-MYC and CCND1 genes at 1 day. The cell number and viability at 1 day along with the gene expression data suggests the peptide is a novel biologically active peptide that will be useful for the investigation of novel therapies for leukemia.

Paper Statistics:

Total View : 371 | Downloads : 362 | Page No: 12-16 |

Cite this Article:
Click here to get all Styles of Citation using DOI of the article.