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ISSN:2454-4116

International Journal of New Technology and Research

Impact Factor 3.953

(An ISO 9001:2008 Certified Online Journal)
India | Germany | France | Japan

Enhanced Antibacterial Activity of Curcumin by Combination with Polyurethane Micelles

( Volume 7 Issue 2,February 2021 ) OPEN ACCESS
Author(s):

Shaomin Song, Meihui Yin, Xiaohui Wan, Daoping Yan, Min Yang, Lijiao Yang, Jicong Deng

Keywords:

Curcumin, Polyurethane micelles, Drug resistance, Targeting, Antibacterial

Abstract:

In recent years, the problem of bacterial resistance has become more and more serious. Drug-resistant strains pose a great threat to human health. Infection mortality and corresponding treatment costs have increased, causing a huge social and economic burden. The study found that curcumin (CUR) can inhibit the growth of bacteria such as Escherichia coli and Staphylococcus. In order to develop a new type of antibacterial material to treat bacterial infections, this subject designed and synthesized a curcumin polyurethane micelle (MPEG-CUR-PU). The micelles showed a pH responsive transition from a negative charge to a positive charge, while strongly adhering quickly to negatively charged bacterial surfaces at infectious sites (pH = 5.5) based on electrostatic attraction. MPEG-CUR-PU has a good selectivity for bacteria, which makes it a promising antibacterial nanodrug in biomedical field.

DOI DOI :

https://doi.org/10.31871/IJNTR.7.2.15

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