Click Here for
Track Your Paper
ISSN:2454-4116

International Journal of New Technology and Research

Impact Factor 3.953

(An ISO 9001:2008 Certified Online Journal)
India | Germany | France | Japan

Clinical and Molecular Anatomy of Gastrointestinal Stromal Tumors (GIST)

( Volume 2 Issue 4,April 2016 ) OPEN ACCESS
Author(s):

Giorgio Maria Paolo Graziano, Giovanni Castelli, Prof Anthony Graziano

Abstract:

Introduction  Gastrointestinal stromal tumors GISTs are rare and fall into the category of non-epithelial tumors of the gastrointestinal tract , involving the stomach at a higher percentage (70 %). The purpose of this study , through a retrospective analysis of the observed cases , is to obtain data on the incidence , survival curve identification of prognostic and predictive parameters .The goal is to collect data concerning the natural history of GIST , 65% of patients were female, 35% male , mean age 64 years. Metastatic disease was assessed by cd171. In this study, n 11 (65 %) cases were L1 ( cd171 ) positive for smooth muscle tumors . Of which 8 with headquarters in the stomach, ileum en 3 . Investigations have been performed immunohistochemistry with CD117 , CD99 , ema .  all enrolled patients tested positive for CD117 .Discussion Thread What are the prognostic factors of GiST is still a matter of debate, but the consensus conference (NIH) in 2001 defined BETHESTHA n 2 parameters which are: the size and mitotic index of 50 HP for the lesions found were reported as accidental the size ranged < 10mm to > 50mm . . . The study carried out shows that the markers are the key to the histological diagnosis of GIST malignancies in GIST have introduced anti-angiogenic therapy with administration of sunitinib at a dose of 50mg/die for 4 weeks every 6 . For the purpose of inhibiting tumor growth with a time of disease-free interval longer. It is evident that in the histological diagnosis of GIST are inserted reporting the results of molecular biology with immunohistochemical markers , in combination with mitotic index , and tumor size in order to define a complete  risks MTS

 

Paper Statistics:

Total View : 687 | Downloads : 678 | Page No: 110-114 |

Cite this Article:
Click here to get all Styles of Citation using DOI of the article.